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严重再生障碍性贫血患者接受ABO血型不合异基因骨髓移植后外周血细胞的再生

Regeneration of peripheral blood cells following ABO incompatible allogeneic bone marrow transplantation for severe aplastic anaemia.

作者信息

Hows J M, Chipping P M, Palmer S, Gordon-Smith E C

出版信息

Br J Haematol. 1983 Jan;53(1):145-51. doi: 10.1111/j.1365-2141.1983.tb01996.x.

DOI:10.1111/j.1365-2141.1983.tb01996.x
PMID:6336649
Abstract

The regeneration of peripheral blood cells in six patients receiving ABO incompatible bone marrow transplants for severe aplastic anaemia has been studied. The results are compared with those of 18 similar aplastic patients treated with ABO compatible transplants. Reticulocyte recovery in the ABO incompatible cases was significantly delayed (P less than 0.01) and associated with greatly prolonged red cell transfusion requirements (P less than 0.001). Peripheral blood regeneration of neutrophils, lymphocytes and platelets was also significantly delayed (P less than 0.01). Platelet support was required for longer in the ABO incompatible cases (P less than 0.001) but there was no increase in the incidence or severity of infections in the post transplant period.

摘要

对6例因严重再生障碍性贫血接受ABO血型不相容骨髓移植患者的外周血细胞再生情况进行了研究。将结果与18例接受ABO血型相容移植的类似再生障碍性贫血患者的结果进行了比较。ABO血型不相容病例的网织红细胞恢复明显延迟(P<0.01),并伴有红细胞输血需求大大延长(P<0.001)。中性粒细胞、淋巴细胞和血小板的外周血再生也明显延迟(P<0.01)。ABO血型不相容病例需要更长时间的血小板支持(P<0.001),但移植后感染的发生率和严重程度没有增加。

相似文献

1
Regeneration of peripheral blood cells following ABO incompatible allogeneic bone marrow transplantation for severe aplastic anaemia.严重再生障碍性贫血患者接受ABO血型不合异基因骨髓移植后外周血细胞的再生
Br J Haematol. 1983 Jan;53(1):145-51. doi: 10.1111/j.1365-2141.1983.tb01996.x.
2
Regeneration of peripheral blood cells following allogeneic bone marrow transplantation for severe aplastic anaemia.严重再生障碍性贫血异基因骨髓移植后外周血细胞的再生
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Hemolysis of transfused group O red blood cells in minor ABO-incompatible unrelated-donor bone marrow transplants in patients receiving cyclosporine without posttransplant methotrexate.在接受环孢素且移植后未使用甲氨蝶呤的患者中,次要ABO血型不相合的无关供者骨髓移植中输注的O型红细胞的溶血情况。
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Bone marrow transplantation with major ABO blood group incompatibility using erythrocyte depletion of marrow prior to infusion.在输注前通过去除骨髓中的红细胞进行主要ABO血型不合的骨髓移植。
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Blut. 1986 Nov;53(5):379-90. doi: 10.1007/BF00321100.