Granato P A, Jurek E A, Weiner L B
Am J Clin Pathol. 1983 Jan;79(1):73-7. doi: 10.1093/ajcp/79.1.73.
A total of 94 clinical isolates of Haemophilus influenzae were studied to analyze the relationship of biotype to site of isolation, serotype, and pattern of antimicrobial susceptibility. Systemic infections were caused most commonly by biotype I, and the majority of these isolates possessed type b capsular polysaccharide. Other noncapsulated biotypes of H. influenzae, particularly biotype V, also were associated with invasive disease. Antimicrobial susceptibility testing was performed on all isolates by an agar dilution method against ampicillin, chloramphenicol, cefoxitin, rifampin, and rosoxacin, and all isolates were screened for beta-lactamase activity. Except for 15 isolates that produced beta-lactamase, no other substantial differences in antimicrobial susceptibilities among biotypes of H. influenzae were detected. Encapsulated strains of biotype I had the highest frequency of ampicillin resistance.
共研究了94株流感嗜血杆菌临床分离株，以分析生物型与分离部位、血清型及抗菌药物敏感性模式之间的关系。全身性感染最常见由生物型I引起，这些分离株中的大多数具有b型荚膜多糖。流感嗜血杆菌的其他无荚膜生物型，特别是生物型V，也与侵袭性疾病有关。采用琼脂稀释法对所有分离株进行了针对氨苄西林、氯霉素、头孢西丁、利福平和罗索沙星的抗菌药物敏感性试验，并对所有分离株进行了β-内酰胺酶活性筛查。除15株产生β-内酰胺酶的分离株外，未检测到流感嗜血杆菌生物型之间在抗菌药物敏感性方面有其他实质性差异。生物型I的包膜菌株氨苄西林耐药频率最高。
