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银屑病中表皮纤溶酶原激活物活性与疾病活动度的相关性

Correlation of epidermal plasminogen activator activity with disease activity in psoriasis.

作者信息

Fraki J E, Lazarus G S, Gilgor R S, Marchase P, Singer K H

出版信息

Br J Dermatol. 1983 Jan;108(1):39-44. doi: 10.1111/j.1365-2133.1983.tb04577.x.

DOI:10.1111/j.1365-2133.1983.tb04577.x
PMID:6336944
Abstract

The specific activity of plasminogen activator was increased in clinically involved psoriatic epidermis compared with the uninvolved skin of the same eight patients. Alterations in plasminogen activator activity correlated with disease activity as measured by extent of body surface involved with psoriasis. Levels of plasminogen activator increased in uninvolved epidermis of psoriatic patients during retinoid therapy.

摘要

与同一8例患者未受累皮肤相比,临床受累的银屑病表皮中纤溶酶原激活剂的比活性增加。纤溶酶原激活剂活性的改变与通过银屑病累及的体表面积衡量的疾病活动相关。在维甲酸治疗期间,银屑病患者未受累表皮中的纤溶酶原激活剂水平升高。

相似文献

1
Correlation of epidermal plasminogen activator activity with disease activity in psoriasis.银屑病中表皮纤溶酶原激活物活性与疾病活动度的相关性
Br J Dermatol. 1983 Jan;108(1):39-44. doi: 10.1111/j.1365-2133.1983.tb04577.x.
2
Uninvolved skin from psoriatic patients develops signs of involved psoriatic skin after being grafted onto nude mice.银屑病患者的未受累皮肤移植到裸鼠身上后会出现受累银屑病皮肤的体征。
Science. 1982 Feb 5;215(4533):685-7. doi: 10.1126/science.7036342.
3
Etretinate treatment for psoriasis inhibits epidermal ornithine decarboxylase.
J Am Acad Dermatol. 1982 Apr;6(4 Pt 2 Suppl):697-8. doi: 10.1016/s0190-9622(82)70059-3.
4
Transplantation of psoriatic skin onto nude mice.
J Invest Dermatol. 1983 Jun;80 Suppl:31s-35s.
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Plasminogen activation in psoriasis.
Acta Derm Venereol Suppl (Stockh). 1989;146:36-8.
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Expression of plasminogen activator enzymes in psoriatic epidermis.纤溶酶原激活剂酶在银屑病表皮中的表达。
J Invest Dermatol. 1994 Mar;102(3):333-8. doi: 10.1111/1523-1747.ep12371792.
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Plasminogen activator in psoriatic scales is of the tissue-type PA as identified by monoclonal antibodies.通过单克隆抗体鉴定,银屑病鳞屑中的纤溶酶原激活物属于组织型纤溶酶原激活物。
Br J Dermatol. 1985 Sep;113(3):257-63. doi: 10.1111/j.1365-2133.1985.tb02076.x.
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Elevated phosphorylase kinase activity in psoriatic epidermis: correlation with increased phosphorylation and psoriatic activity.银屑病表皮中磷酸化酶激酶活性升高:与磷酸化增加及银屑病活动度的相关性。
Br J Dermatol. 1994 Mar;130(3):298-306. doi: 10.1111/j.1365-2133.1994.tb02924.x.
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Plasminogen activator and histone hydrolyzing proteases in psoriasis scales--possible role in increased cell division.银屑病鳞屑中的纤溶酶原激活物和组蛋白水解蛋白酶——在细胞分裂增加中可能发挥的作用
Ann Clin Res. 1976 Oct;8(5):335-9.
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Etretinate therapy for psoriasis: clinical responses, remission times, epidermal DNA and polyamine responses.
J Am Acad Dermatol. 1983 Jan;8(1):95-102. doi: 10.1016/s0190-9622(83)70012-5.

引用本文的文献

1
Fibrinolysis in cornea and conjunctiva: evidence of two types of activators.
Graefes Arch Clin Exp Ophthalmol. 1986;224(5):393-6. doi: 10.1007/BF02173351.
2
Production of plasminogen activator by alveolar macrophages in normal subjects and patients with interstitial lung disease.正常受试者和间质性肺疾病患者肺泡巨噬细胞纤溶酶原激活物的产生。
Thorax. 1988 Jul;43(7):508-15. doi: 10.1136/thx.43.7.508.
3
Hydrolysis of histones by proteinases.蛋白酶对组蛋白的水解作用。
Biochem J. 1988 Mar 15;250(3):859-64. doi: 10.1042/bj2500859.
4
The psoriatic epidermal lesion and anagen hair growth may share the same "switch-on" mechanism.银屑病表皮病变和生长期毛发的生长可能具有相同的“开启”机制。
Yale J Biol Med. 1988 Sep-Oct;61(5):467-76.
5
Decreased specific anti-elastase activity in the uninvolved skin of patients with psoriasis.银屑病患者未受累皮肤中特异性抗弹性蛋白酶活性降低。
Arch Dermatol Res. 1991;283(4):224-9. doi: 10.1007/BF01106106.
6
Basement membrane zone as a target for human neutrophil elastase in psoriasis.基底膜带作为银屑病中人类中性粒细胞弹性蛋白酶的作用靶点。
Arch Dermatol Res. 1990;282(8):506-11. doi: 10.1007/BF00371944.