Avni A, David M P, Pauzner D
Fertil Steril. 1983 Feb;39(2):193-6. doi: 10.1016/s0015-0282(16)46818-4.
The observation of a very severe peritoneal reaction to translocated copper-bearing devices in five women necessitated operative removal. Three Copper-T (Ortho Gyne-T, Ortho, Saunderton, High Wycombe, England) and two Copper-7 (Gravigard, Searle, High Wycombe, England) devices were involved. Similarly severe peritoneal reactions were noted in 90% of female rats who had small-sized modified copper devices inserted into their peritoneal cavities. In a control group of rats with the same device but without a copper wire, mild adhesions were observed in the majority (85%), and none had a severe peritoneal reaction. It seems evident that the severe peritoneal reaction is induced by the copper wire in both women and female rats.
观察到五名女性对移位的含铜节育器出现非常严重的腹膜反应，因此必须进行手术取出。涉及三个铜-T型（奥索吉内-T，奥索公司，桑德顿，海威科姆，英国）和两个铜-7型（格拉维加德，塞尔公司，海威科姆，英国）节育器。同样，在90%将小型改良铜节育器植入腹腔的雌性大鼠中也观察到了严重的腹膜反应。在一组使用相同节育器但无铜线的对照大鼠中，大多数（85%）出现了轻度粘连，没有一只出现严重的腹膜反应。很明显，严重的腹膜反应在女性和雌性大鼠中都是由铜线引起的。
