Demain A L
Science. 1983 Feb 11;219(4585):709-14. doi: 10.1126/science.6337397.
Microbial secondary metabolites are now being used for applications other than as antibacterial, antifungal, and antitumor agents. These applications include use against parasites (coccidia, helminths) and insects as well as for animal and plant growth stimulation, immunosuppression, uterocontraction, and other pharmacological activities. Further applications are possible in various areas of pharmacology and agriculture, a development catalyzed by the use of simple enzyme assays for screening prior to testing in intact animals or in the field.
微生物次级代谢产物目前正被用于抗菌、抗真菌和抗肿瘤药物以外的其他用途。这些用途包括用于对抗寄生虫(球虫、蠕虫)和昆虫,以及用于刺激动植物生长、免疫抑制、子宫收缩和其他药理活性。通过在完整动物或田间试验之前使用简单的酶测定法进行筛选,药理学和农业的各个领域可能会有进一步的应用发展。