Löwenberg B, van Gijn J, Prins E, Polderman A M
Transplantation. 1983 Jan;35(1):30-4. doi: 10.1097/00007890-198301000-00007.
Although opportunistic infections after allogeneic bone marrow transplantation are common, cerebral toxoplasmosis has only been reported once. We report a case of lethal cerebral toxoplasmosis in a patient with acute leukemia who had been submitted to intensive cytotoxic therapy and allogeneic marrow rescue. The clinical course was characterized by an unusually sudden neurological onset. It was remarkable that, in this case, toxoplasma serology remained repeatedly negative. The autopsy revealed that the infection also involved the myocardium. Serological data and pathology findings are presented.
尽管异基因骨髓移植后的机会性感染很常见，但脑弓形虫病仅被报道过一次。我们报告一例急性白血病患者发生致命性脑弓形虫病的病例，该患者接受了强化细胞毒性治疗和异基因骨髓救援。临床病程的特点是神经系统发病异常突然。值得注意的是，在该病例中，弓形虫血清学检查多次呈阴性。尸检显示感染还累及心肌。本文呈现了血清学数据和病理检查结果。
