Monto G L, Guillan R A, Lee S H, Watanabe I
Am J Gastroenterol. 1983 Feb;78(2):63-7.
Corticosteroid treatment of acute pancreatitis has recently been advocated by clinicians. The effectiveness of steroids in the prevention of pancreatitis was studied in the model of ethionine pancreatitis in rabbits. A group of 20 rabbits received ethionine for 6 days. Methyl prednisolone succinate was also given to half of the group for a period of 6 days. Animals were killed on the 7th day; enzyme determinations were done; tissues from the pancreas and liver were obtained, coded, and read as unknown by the pathologist; and tissue damage categorized. Corticosteroid treatment was associated with greater elevation of serum amylase and other enzymes. Light microscopic examination of pancreas and liver revealed no apparent beneficial effect from corticosteroid treatment. The experiment was repeated with special stains being made of liver and pancreas, and electron microscopic studies of five animals in each group was done. Light microscopy showed little difference in cellular damage between the two groups. Electron microscopy revealed less apparent damage in the steroid treated (methyl prednisolone succinate) animals than controls. Steroids may provide minimal protection on a subcellular level from ethionine pancreatitis.
临床医生最近主张用皮质类固醇治疗急性胰腺炎。在兔乙硫氨酸胰腺炎模型中研究了类固醇预防胰腺炎的有效性。一组20只兔子接受乙硫氨酸处理6天。该组一半的兔子还接受了6天的琥珀酸甲泼尼龙治疗。在第7天处死动物；进行酶测定；获取胰腺和肝脏组织，编码后由病理学家作为未知样本解读，并对组织损伤进行分类。皮质类固醇治疗与血清淀粉酶和其他酶的升高幅度更大有关。胰腺和肝脏的光学显微镜检查未发现皮质类固醇治疗有明显有益效果。重复该实验，对肝脏和胰腺进行特殊染色，并对每组5只动物进行电子显微镜研究。光学显微镜显示两组细胞损伤差异不大。电子显微镜显示，接受类固醇（琥珀酸甲泼尼龙）治疗的动物比对照组的损伤不太明显。类固醇可能在亚细胞水平对乙硫氨酸胰腺炎提供最小程度的保护。
