Kaskel D, Spangenberg U, Rudolf H, Hübel H, Witt N, Baumgart W
Klin Monbl Augenheilkd. 1978 Mar;172(3):356-63.
Radioactively labelled microspheres (size 15 micron) were used to determine the regional blood flow in cats before and 15, 30 and 45 minutes after unilateral drug administration. In four experimental groups, each consisting of five animals, two drops of the drug were administered into the conjunctival sac. The blood flow increased in both eyes after administration of 2% pilocarpine and of Glauko Biciron, a mixture of 2% pilocarpine and 0.06% phenylephrine. No significant differences in the regional blood flows between the treated and untreated eye were found. After administration of 2% phenylephrine a decrease in blood flow was observed in both eyes, however earlier and more pronounced in the left eye. Thus, phenylephrine evoked the expected vasoconstrictive effect on the treated side. In the control group, which received physiological salt solution, the blood flow on the treated side decreased in most tissues, while an increase was observed on the untreated side.
使用放射性标记的微球体（尺寸为15微米）来测定猫在单侧给药前以及给药后15、30和45分钟时的局部血流量。在四个实验组中，每组由五只动物组成，将两滴药物滴入结膜囊。给予2%毛果芸香碱以及Glauko Biciron（2%毛果芸香碱和0.06%去氧肾上腺素的混合物）后，两只眼睛的血流量均增加。在治疗眼和未治疗眼之间未发现局部血流量有显著差异。给予2%去氧肾上腺素后，两只眼睛的血流量均减少，然而左眼更早且更明显。因此，去氧肾上腺素在治疗侧诱发了预期的血管收缩效应。在接受生理盐溶液的对照组中，治疗侧大多数组织的血流量减少，而未治疗侧则观察到血流量增加。
