Sega R, Mailland F, Damiani E, Groothold G, Libretti A
Clin Pharmacol Ther. 1983 Mar;33(3):289-93. doi: 10.1038/clpt.1983.35.
After a complete washout 14 hypertensive inpatients were given placebo for 3 days. Undistinguishable 30- or 60-mg indenolol tablets were then given twice daily for 14 days in a double-blind, randomized manner. Supine and standing arterial pressure and heart rate were measured at rest three times a day. Indenolol decreased systolic and diastolic arterial pressure as well as heart rate in subjects in supine and standing positions. Placebo had no effect. The effect of indenolol on systolic arterial pressure was dose and time related, but independent of the intensity of hypertension. No dose-effect relationship was found on diastolic arterial pressure. Decrease of heart rate was dose and time related, although bradycardia was never noted. Indenolol was well tolerated.
在经过彻底洗脱期后，14名高血压住院患者服用了3天安慰剂。然后以双盲、随机的方式，每天两次给予无法区分的30毫克或60毫克吲哚洛尔片，持续14天。每天三次在静息状态下测量仰卧位和站立位的动脉血压及心率。吲哚洛尔可降低仰卧位和站立位受试者的收缩压和舒张压以及心率。安慰剂则无效果。吲哚洛尔对收缩压的作用与剂量和时间相关，但与高血压的严重程度无关。在舒张压方面未发现剂量 - 效应关系。心率的降低与剂量和时间相关，尽管从未观察到心动过缓。吲哚洛尔耐受性良好。
