The management of septic shock.

Septic shock is a common emergency, most often caused by gram-negative bacteremia. Appearance of gram-negative endotoxin in the systemic circulation sets off a complex reaction involving many physiologic systems. The resultant reduction in microcirculation and subsequent organ dysfunction often lead to death. Early therapy to support the cardiovascular system and rational antibiotic therapy may improve the chance of survival. Careful monitoring of disease and drug effect parameters is essential to therapy.