Sangaiah R, Gold A, Toney G E, Toney S H, Claxton L, Easterling R, Nesnow S
Mutat Res. 1983 Mar;119(3):259-66. doi: 10.1016/0165-7992(83)90170-7.
Initial studies on the mutagenicity and metabolism of a novel cyclopenta-PAH, benz[j]aceanthrylene, are reported in the Salmonella bacterial system. The spectrum of activity of benz[j]aceanthrylene over the 5 Ames tester strains is similar to that of benzo[a]pyrene, and the dose-response curves for strain TA98 are comparable. Like other biologically active PAH, benz[j]aceanthrylene is a frame-shift mutagen requiring metabolic activation. An interesting feature of the S9 dependence of activity is the low concentration (congruent to 10-fold smaller than for benzo[a]pyrene) at which optimal activity is observed. The 1,2-dihydro-1,2-diol (product of metabolism of the cyclopenta-ring) appears to be the predominant metabolite, and implicates the 1,2-oxide as the ultimate mutagenic species.
本文报道了在沙门氏菌系统中对一种新型环戊并多环芳烃——苯[j]埃蒽的致突变性和代谢情况的初步研究。苯[j]埃蒽在5种艾姆斯试验菌株上的活性谱与苯并[a]芘相似，且TA98菌株的剂量反应曲线具有可比性。与其他具有生物活性的多环芳烃一样，苯[j]埃蒽是一种需要代谢激活的移码诱变剂。活性对S9依赖性的一个有趣特征是，在较低浓度下（比苯并[a]芘低约10倍）可观察到最佳活性。1,2-二氢-1,2-二醇（环戊环的代谢产物）似乎是主要代谢物，并表明1,2-环氧化物是最终的诱变物质。
