Eisenbrandt D L, Phemister R D
Lab Invest. 1978 Mar;38(3):225-31.
Quantitative morphology was used to investigate injury induced in the developing canine kidney by ionizing radiation. Irradiation at 2 days of age destroyed nephrogenic tissue in the outer renal cortex and significantly reduced kidney weight and volume through 70 days of age. However, as early as 14 days of age and continuing through 200 days of age, hypertrophy was demonstrated in the surviving middle and inner cortical nephrons of these kidneys. Both corpuscular and tubular components of the nephrons grew at an accelerated rate as compared to controls. The corpuscular volume per nephron increased 559 per cent in irradiated dogs and only 249 per cent in controls from 14 to 200 days of age. The tubular volume per nephron increased 519 per cent in irradiated dogs and 303 per cent in controls during the same period. As a result of the compensatory growth in individual nephrons, the kidneys of irradiated dogs at 200 days of age were as large as the controls when compared on the basis of body weight. The extensive hypertrophy is associated with accelerated development of intercapillary glomerulosclerosis in dogs irradiated around the time of birth.
采用定量形态学方法研究电离辐射对发育中的犬肾造成的损伤。出生2天时接受辐射会破坏肾外皮质的肾发生组织，并在70日龄前显著降低肾脏重量和体积。然而，早在14日龄时，这些肾脏存活的中皮质和内皮质肾单位就开始出现肥大，并持续到200日龄。与对照组相比，肾单位的肾小球和肾小管成分均加速生长。从14日龄到200日龄，受辐射犬每个肾单位的肾小球体积增加了559%，而对照组仅增加了249%。同期，受辐射犬每个肾单位的肾小管体积增加了519%，对照组增加了303%。由于单个肾单位的代偿性生长，200日龄时受辐射犬的肾脏与对照组基于体重比较时大小相同。广泛的肥大与出生前后接受辐射的犬的毛细血管间肾小球硬化加速发展有关。
