Nagle R B, Bulger R E
Lab Invest. 1978 Mar;38(3):270-8.
The late histologic and ultrastructural effects of complete unilateral ureteral obstruction in the rabbit kidney were studied from 7 to 32 days postobstruction. Papillary necrosis occurred in all animals by the 7th day. There was progressive widening of the cortical interstitial space with proliferation of fibroblasts. Increased interstitial collagen fibers first became apparent on the 7th day and showed a progressive increase with time. The fibroblasts underwent myofibroblast transformation beginning on the 7th day. All segments of the nephron showed ultrastructural evidence of sublethal cell injury with loss of cell specialization. The dedifferentiation of the tubular cells was associated with a repetitive formation of new lamellae of basement membrane on the luminal side of the original basement membranes beginning on the 16th day of obstruction. These morphologic changes are discussed in terms of the physiologic changes previously reported in this model and the known clinical abnormalities found in obstructive uropathy.
研究了兔肾完全性单侧输尿管梗阻后7至32天的晚期组织学和超微结构变化。到第7天时，所有动物均出现乳头坏死。随着成纤维细胞增殖，皮质间质间隙逐渐增宽。间质胶原纤维增加在第7天首次明显出现，并随时间逐渐增加。成纤维细胞从第7天开始发生肌成纤维细胞转化。肾单位的所有节段均显示亚致死性细胞损伤的超微结构证据，细胞特化丧失。肾小管细胞的去分化与梗阻第16天开始在原始基底膜腔面重复形成新的基底膜板层有关。根据该模型先前报道的生理变化以及梗阻性肾病中已知的临床异常情况对这些形态学变化进行了讨论。
