Baraboĭ V A, Sutkovoĭ D A
Ukr Biokhim Zh (1978). 1983 Jan-Feb;55(1):93-105.
Normal hormonal regulation of energy metabolism is mainly realized by glucocorticoids and insulin, their physiological antagonist. Under the effect of different extremal factors (including ionizing radiation) there arises non-specific stress, a syndrome the main component of which is the hyperfunction of glucocorticoids--the intermediate hormonal link in the stress reaction. Stimulation of hypercorticism by administering hydrocortisone to intact animals as well as its stimulation by administering this preparation to irradiated animals causes development and intensification of inhibition and uncoupling of the oxidative phosphorylation as well as disturbance in adenylic nucleotides metabolism. The administered insulin, softening the reaction of hypercorticism and changing the ratio of the hormone levels in favour of insulin, weakens essentially the stress (ray) disturbances in the energy metabolism.
能量代谢的正常激素调节主要由糖皮质激素及其生理拮抗剂胰岛素实现。在不同极端因素（包括电离辐射）的作用下，会出现非特异性应激，该综合征的主要成分是糖皮质激素功能亢进——应激反应中的中间激素环节。给未受照射的动物注射氢化可的松刺激肾上腺皮质功能亢进，以及给受照射动物注射该制剂刺激肾上腺皮质功能亢进，都会导致氧化磷酸化的抑制和解偶联的发展与加剧，以及腺苷酸代谢紊乱。注射胰岛素可减轻肾上腺皮质功能亢进反应，改变激素水平比例使其有利于胰岛素，从而基本减轻能量代谢中的应激（辐射）紊乱。
