Geboes K, Rutgeerts P, Vantrappen G, Desmet V J
Hepatogastroenterology. 1983 Feb;30(1):24-6.
Alpha-1-antitrypsin (AAT) was detected by an indirect immunofluorescent technique and a peroxidase antiperoxidase technique in the human colon. It was present along the luminal border, in Paneth cells, in occasional epithelial cells and in macrophages. In idiopathic inflammatory bowel diseases an increased number of AAT positive macrophages can be seen. Although AAT is scarcely present in the human it might play a role in a local defence mechanism and thus in the pathogenesis of inflammatory bowel diseases.
采用间接免疫荧光技术和过氧化物酶抗过氧化物酶技术在人结肠中检测到α-1-抗胰蛋白酶（AAT）。它存在于管腔边界、潘氏细胞、偶尔的上皮细胞和巨噬细胞中。在特发性炎症性肠病中，可以看到AAT阳性巨噬细胞数量增加。虽然AAT在人体内含量稀少，但它可能在局部防御机制中发挥作用，进而在炎症性肠病的发病机制中发挥作用。
