肌动蛋白参与心脏Z线和Z线类似物的证据。
Evidence for actin involvement in cardiac Z-lines and Z-line analogues.
作者信息
Yamaguchi M, Robson R M, Stromer M H
出版信息
J Cell Biol. 1983 Feb;96(2):435-42. doi: 10.1083/jcb.96.2.435.
Abstract
Canine and feline cardiac Z-lines and Z-rods were examined by electron microscopy before and after digestion of muscle fibers with Ca2+-activated protease (CAF). Removal by CAF of electron-dense material which covers Z-lines and Z-rods exposed interdigitating longitudinal filaments (6-7 nm in diameter) apparently continuous with thin filaments of the respective I-bands. The newly exposed longitudinal filaments of CAF-treated Z-lines and of CAF-treated Z-rods bound heavy meromyosin and therefore are actin. The width of Z-lines and length of Z-rods are determined by the amount of overlap of actin filaments of opposite polarity. The oblique filaments in Z-lines and Z-rods are responsible for the perpendicular periodicity of Z-lines and Z-rods, and are attributed to alpha-actinin.
摘要
在用钙离子激活蛋白酶（CAF）消化肌纤维前后，通过电子显微镜对犬类和猫类心脏的Z线和Z棒进行了检查。CAF去除覆盖Z线和Z棒的电子致密物质后，暴露出相互交错的纵向细丝（直径6-7纳米），这些细丝显然与各自I带的细肌丝相连。经CAF处理的Z线和经CAF处理的Z棒新暴露的纵向细丝结合了重酶解肌球蛋白，因此是肌动蛋白。Z线的宽度和Z棒的长度由相反极性的肌动蛋白丝的重叠量决定。Z线和Z棒中的斜向细丝决定了Z线和Z棒的垂直周期性，并且归因于α-辅肌动蛋白。
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