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多剂量瓶与单剂量瓶：一项关于无菌性和成本效益的研究。

Multidose vials versus single-dose vials: a study in sterility and cost-effectiveness.

作者信息

Sheth N K, Post G T, Wisniewski T R, Uttech B V

出版信息

J Clin Microbiol. 1983 Feb;17(2):377-9. doi: 10.1128/jcm.17.2.377-379.1983.

DOI:10.1128/jcm.17.2.377-379.1983
PMID:6339554
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC272643/
Abstract

A total of 197 multidose injectable vials were collected from 10 different nursing stations and evaluated for sterility. Experimental contamination studies were undertaken, and the cost-effectiveness of multidose vials was compared with that of single-dose vials. Our results showed that bacterial contamination of multidose injectable vials was not a significant hazard; in addition, contrary to common belief, the use of multidose vials was not always successful as a cost-containment measure.

摘要

从10个不同的护理站收集了总共197个多剂量注射瓶，并对其无菌性进行评估。开展了实验性污染研究，并将多剂量瓶与单剂量瓶的成本效益进行比较。我们的结果表明，多剂量注射瓶的细菌污染并非重大风险；此外，与普遍看法相反，使用多剂量瓶作为成本控制措施并非总是成功的。

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本文引用的文献

1
A study of contamination of multiple-dose medication vials.
Hospitals. 1962 Jul 16;36:78.
2
POTENTIAL HEALTH HAZARDS IN THE MULTIPLE-DOSE VIAL.
Hospitals. 1964 Jun 16;38:71-4.
3
Sterility of multiple dose vials after repeated use.
Am Surg. 1958 Nov;24(11):811-4.
4
Growth of nosocomial pathogens in multiple-dose parenteral medication vials.多剂量注射用药品小瓶中医院病原体的生长情况。
J Clin Microbiol. 1982 Jun;15(6):1024-8. doi: 10.1128/jcm.15.6.1024-1028.1982.
5
The sterility of multiple-dose vials in challenged.
Hosp Manage. 1967 Jul;104(1):67-72.
6
Multiple dose vials: a source of contamination?多剂量瓶：污染源？
J S C Med Assoc. 1968 Nov;64(11):461-4.
7
Bacterial killing by bacteriostatic saline solutions--potential for diagnostic error.
N Engl J Med. 1973 Oct 11;289(15):794-5. doi: 10.1056/NEJM197310112891508.
8
Study shows contamination in multiple-dose vials.
AORN J. 1973 May;17(5):111-4. doi: 10.1016/s0001-2092(07)60791-1.
9
Studies on in-use microbial contamination of multiple-dose vials.多剂量瓶使用过程中的微生物污染研究。
Acta Pharm Suec. 1978;15(6):401-5.