Ceilley R I, Bumsted R M, Panje W R
J Dermatol Surg Oncol. 1983 Apr;9(4):288-93. doi: 10.1111/j.1524-4725.1983.tb00804.x.
The use of skin grafts on granulating wounds is an established practice. Delaying the application of a full- or split-thickness skin graft may be an advantageous alternative method of surgical reconstruction in selected cases. Partial healing by secondary intention is useful for filling in deeper defects and usually produces a wound that is much smaller and of more normal contour than the original defect. Contraction of the graft bed is markedly influenced by location, tissue laxity, surface tension lines, motion, and wound geometry. Proper wound care, correct surgical preparation of the defect, and timing of the graft procedure are all important considerations in maximizing the overall result. Through-and-through defects and wounds produced over areas with little underlying support (eyelids and lip) often need flap reconstruction or immediate grafting to prevent undesirable functional and cosmetic results. By combining delayed healing and conventional reconstructive techniques, major tissue loss can often be restored while minimizing patient morbidity.
在肉芽创面上使用皮肤移植是一种既定的做法。在某些情况下，延迟应用全厚或中厚皮肤移植可能是一种有利的手术重建替代方法。二期愈合有助于填充较深的缺损，通常产生的创面比原始缺损小得多且轮廓更接近正常。移植床的收缩受到位置、组织松弛度、表面张力线、运动和伤口几何形状的显著影响。在使整体效果最大化方面，适当的伤口护理、对缺损进行正确的手术准备以及移植手术的时机都是重要的考虑因素。贯通性缺损以及在几乎没有深层支撑的区域（眼睑和唇部）产生的伤口通常需要皮瓣重建或立即移植，以防止出现不良的功能和美容效果。通过结合延迟愈合和传统重建技术，通常可以在使患者发病率降至最低的同时修复大面积组织缺损。
