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通过细胞内电解质冲洗后冷藏保存的进口肾脏与本地获取肾脏的比较。

Comparison of imported with locally retrieved kidneys preserved by intracellular electrolyte flushing followed by cold storage.

作者信息

Barry J M, Fischer S, Larson B, Fearey J A, Lieberman C, Fuchs E F

出版信息

J Urol. 1983 Mar;129(3):471-2. doi: 10.1016/s0022-5347(17)52184-9.

Abstract

Ice-cold intracellular electrolyte flushing followed by cold storage and economy air shipment is the cheapest method to share kidneys for transplantation. This study from 1 center compares 62 primary cadaver kidney grafts imported from other centers to 128 that were retrieved locally. Cold ischemia time was 36.4 plus or minus 8.6 hours (mean plus or minus standard deviation) in the imported group and 24.2 plus or minus 8.8 hours in the locally retrieved group. The significant increase in first week dialysis (71 versus 42 per cent) and 1-month serum creatinine nadirs (2.63 plus or minus 2.73 versus 1.78 plus or minus 1.04 mg./dl.) was explained by longer cold ischemia times in the imported kidney grafts. There were no significant differences between the 2 groups with respect to actuarial kidney graft survivals and serum creatinine levels at 1, 2 and 3 years. Intracellular electrolyte flushing followed by simple cold storage and air transportation provides kidney graft survivals and long-term kidney graft function at minimal expense when the kidneys are retrieved from beating-heart cadavers and have undergone minimal warm ischemia.

摘要

采用冰冷的细胞内电解质冲洗,随后进行冷藏并通过经济舱空运,是分享移植肾脏的最便宜方法。这项来自1个中心的研究,将从其他中心进口的62例原发性尸体肾移植物与128例在当地获取的肾移植物进行了比较。进口组的冷缺血时间为36.4±8.6小时(均值±标准差),而当地获取组为24.2±8.8小时。进口肾移植物较长的冷缺血时间解释了第一周透析率显著增加(71%对42%)以及1个月时血清肌酐最低点升高(2.63±2.73对1.78±1.04mg./dl.)的原因。在移植肾存活 actuarial 率以及1年、2年和3年时的血清肌酐水平方面,两组之间没有显著差异。当肾脏从心跳骤停的尸体获取且经历的热缺血时间极短时,采用细胞内电解质冲洗,随后进行简单冷藏和航空运输,能以最低成本实现肾移植物存活和长期肾移植物功能。

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