肝硬化患者血浆组胺浓度及血流动力学变化（作者译）
[Plasma histamine concentration and hemodynamic changes in liver cirrhosis (author's transl)].
作者信息
Stopik D, Hampel K E, Beger H G
出版信息
Leber Magen Darm. 1978 Apr;8(2):91-3.
Different causal factors have been speculated about in regard to hemodynamic changes (hyperdynamic circulation) in liver cirrhosis. Effects of various vasoactive substances upon the increased arterio-venous intrapulmonary shunting in cirrhosis have been demonstrated, including reduced ferritin, bradykinin, prostaglandins, VIP and parenterally applied histamine. In cirrhotic patients pre- and posthepatic plasma concentrations of histamine are definitely elevated, and elimination of histamine by the liver is reduced. It is speculated, that elevated plasma concentrations of endogenous histamine may contribute to hemodynamic changes in liver cirrhosis.
关于肝硬化时的血流动力学变化（高动力循环），人们推测了不同的因果因素。已经证实了各种血管活性物质对肝硬化时肺内动静脉分流增加的影响，包括铁蛋白减少、缓激肽、前列腺素、血管活性肠肽和经胃肠外给药的组胺。肝硬化患者肝前和肝后血浆组胺浓度确实升高，且肝脏对组胺的清除减少。据推测，内源性组胺血浆浓度升高可能导致肝硬化时的血流动力学变化。
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