Gottrup F
Acta Chir Scand. 1983;149(1):57-62.
Mechanical properties, rupture pattern (morphologic characteristics) and distribution of collagen concentration in incisional wounds of rat stomach and duodenum after 80 days of healing were compared with previous observations on 40-day wounds and with intact tissue. Increased energy absorption (breaking energy) was found in wound tissue of stomach and duodenum after 80 days. No other differences were found between 40 and 80 days of healing. The weakest point of the healing wound was 4-5 mm lateral to the incision line, in the margin of the biochemically active zone. The results indicate that the functionally important part of the healing process in stomach and duodenum occurs early, but some activity persists for at least 80 days postoperatively. The main activity in late wound healing probably is remodelling of scar tissue, completing restoration of tissue strength. Suture materials and technique are unimportant for late healing phases in stomach and duodenum. It is emphasized that a detailed biomechanical account of wound properties is necessary to describe the development of a wound's mechanical strength.
将大鼠胃和十二指肠切口愈合80天后的机械性能、破裂模式（形态学特征）以及胶原浓度分布与之前对40天伤口的观察结果和完整组织进行了比较。发现80天后胃和十二指肠伤口组织的能量吸收（断裂能）增加。在愈合40天和80天之间未发现其他差异。愈合伤口的最薄弱点位于切口线外侧4-5毫米处，在生化活性区边缘。结果表明，胃和十二指肠愈合过程中功能上重要的部分发生在早期，但术后至少80天仍有一些活动持续。伤口晚期愈合的主要活动可能是瘢痕组织的重塑，完成组织强度的恢复。缝合材料和技术对胃和十二指肠的晚期愈合阶段并不重要。需要强调的是，对伤口特性进行详细的生物力学描述对于描述伤口机械强度的发展是必要的。
