Chapman R M
Am J Ind Med. 1983;4(1-2):149-61.
Radiation, alkylating agents and the vinca alkaloids produce variable degrees of gonadal dysfunction in humans; additional drugs have been linked to gonadal damage in males only. Age at time of exposure and total dose of drug administered are associated with the degree of gonadal injury. Irreversible sterility develops at lower doses in men than in women. The infertile men usually retain sexual function, whereas the infertile women experience premature menopause and sexual dysfunction. Subfertility with normal sexual function is the sequela of lesser degrees of gonadal injury in men and women. For a given drug dose, children apparently sustain less gonadal damage than their adult counterparts. Rigorous reporting of basic essential data will enhance our understanding of drug-induced gonadal damage; incomplete reports only cloud the issue.
辐射、烷化剂和长春花生物碱可在人类中产生不同程度的性腺功能障碍；其他药物仅与男性性腺损伤有关。接触时的年龄和给药的总剂量与性腺损伤程度相关。男性在较低剂量下就会出现不可逆的不育，而女性则不然。不育男性通常保留性功能，而不育女性会经历过早绝经和性功能障碍。性功能正常但生育力低下是男性和女性性腺损伤程度较轻的后遗症。对于给定的药物剂量，儿童显然比成年人遭受的性腺损伤更少。严格报告基本必要数据将增进我们对药物性性腺损伤的理解；不完整的报告只会使问题变得模糊。
