Yoo T J, Tomoda K, Stuart J M, Kang A H, Townes A S
Ann Otol Rhinol Laryngol. 1983 Mar-Apr;92(2 Pt 1):103-8. doi: 10.1177/000348948309200201.
Otospongiosis-like lesions were induced in rats by immunizing them with native type II collagen. Immunized rats had antibody responses specific for native type II collagen and developed otospongiosis-like lesions. The spongiotic lesion was characterized by numerous osteocytes and osteoblasts in the vascular spaces and by dark staining probably due to the chemical alteration of ground substances. Bone resorption and new bone formation were clearly visible. Immunofluorescence studies demonstrated deposition of immunoglobulin and complement on the bone matrix and wall within the area of spongiosis. An antibody-mediated etiopathogenesis was suspected.
通过用天然II型胶原蛋白免疫大鼠，在大鼠中诱导出耳硬化样病变。免疫后的大鼠对天然II型胶原蛋白产生特异性抗体反应，并出现耳硬化样病变。海绵状病变的特征是血管间隙中有大量骨细胞和成骨细胞，以及可能由于基质化学改变而导致的深色染色。骨吸收和新骨形成清晰可见。免疫荧光研究表明免疫球蛋白和补体沉积在海绵状病变区域内的骨基质和骨壁上。怀疑存在抗体介导的发病机制。
