Aimoto S, Watanabe H, Ikemura H, Shimonishi Y, Takeda T, Takeda Y, Miwatani T
Biochem Biophys Res Commun. 1983 Apr 15;112(1):320-6. doi: 10.1016/0006-291x(83)91833-8.
A shorter analog of a heat-stable enterotoxin produced by a human strain of enterotoxigenic Escherichia coli SK-1, consisting of 14 amino acid residues including 6 half-cystine residues, was synthesized by conventional methods. The peptide was evaluated for ability to induce intestinal secretion in suckling mice and for stability at high temperature under various conditions. The peptide was 2-5 times more potent than native toxin and was still toxic after heat-treatment at 120 degrees C for 30 min.
通过常规方法合成了一种由产肠毒素性大肠杆菌SK-1人菌株产生的热稳定肠毒素的较短类似物，其由14个氨基酸残基组成，包括6个半胱氨酸残基。对该肽在乳鼠中诱导肠道分泌的能力以及在各种条件下高温下的稳定性进行了评估。该肽的效力比天然毒素高2至5倍，在120℃热处理30分钟后仍具有毒性。
