Sankaran H, Deveney C W, Bartholomew C, Raghupathy E
Biochem Pharmacol. 1983 Mar 15;32(6):1101-4. doi: 10.1016/0006-2952(83)90632-9.
In vivo, canine pancreas was stimulated to secrete insulin by the venom of the scorpion Tityus trinitatis; the venom also caused a rise in plasma glucose level as well. The venom-induced insulin secretion was also observed under in vitro conditions in rat pancreatic slices, and this stimulation was dose-related. Maximal effect was observed at 20 micrograms/ml. Atropine (3 x 10(-6) M) completely abolished both venom (20 micrograms/ml)- and acetylcholine (3 x 10(-7) M)-induced insulin secretion. It is suggested that the venom-induced insulin secretion is mediated through muscarinic cholinergic mechanisms.
在体内，通过特立尼达三色蝎的毒液刺激犬胰腺分泌胰岛素；该毒液还导致血浆葡萄糖水平升高。在体外条件下，在大鼠胰腺切片中也观察到了毒液诱导的胰岛素分泌，且这种刺激与剂量相关。在20微克/毫升时观察到最大效应。阿托品（3×10⁻⁶ M）完全消除了毒液（20微克/毫升）和乙酰胆碱（3×10⁻⁷ M）诱导的胰岛素分泌。提示毒液诱导的胰岛素分泌是通过毒蕈碱胆碱能机制介导的。
