Patel M K, Evans C E, McEvoy F A
Biosci Rep. 1983 Jan;3(1):53-60. doi: 10.1007/BF01121571.
Prostacyclin, being a potent vasodilator and platelet aggregation inhibitor, is of interest because of its possible relationship to microangiopathy associated with diabetes and other vascular diseases. Using a radioimmunoassay for the stable product of prostacyclin breakdown (6-keto PGF1 alpha) we have examined the ability of serum from diabetic patients to stimulate prostacyclin production in human endothelial cells. Results in the study of the effects of human serum on prostacyclin production by endothelial cells showed that there was a highly significant difference between diabetics and controls, with diabetic serum causing much lower prostacyclin production from cultured cells. The effect of serum in this study was not dependent on the age or sex of the donor.
前列环素作为一种强效血管舒张剂和血小板聚集抑制剂，因其与糖尿病及其他血管疾病相关的微血管病变可能存在关联而备受关注。我们运用放射免疫分析法检测前列环素分解的稳定产物（6-酮-前列腺素F1α），研究了糖尿病患者血清刺激人内皮细胞产生前列环素的能力。关于人血清对内皮细胞产生前列环素影响的研究结果表明，糖尿病患者与对照组之间存在高度显著差异，糖尿病患者血清使培养细胞产生的前列环素量低得多。本研究中血清的作用不依赖于供体的年龄或性别。
