单独使用甲氧苄啶与复方新诺明和磺胺甲噻二唑治疗尿路感染的比较。
Comparison of trimethoprim alone with co-trimoxazole and sulphamethizole for treatment of urinary tract infections.
作者信息
Keenan T D, Eliott J C, Bishop V, Peddie B A, Bailey R R
出版信息
N Z Med J. 1983 May 11;96(731):341-2.
This study was undertaken to compare the effectiveness of trimethoprim alone (300 mg daily) with both cotrimoxazole (0.96 g 12-hourly) and sulphamethizole (1 g eight-hourly) for the treatment of uncomplicated urinary tract infections in general practice. Treatment was continued for five days in all patients. Twenty patients were included in each group. The cure rates (sterile urine one week after finishing treatment) for trimethoprim, co-trimoxazole and sulphamethizole were 90, 95 and 90% respectively. Side effects were minimal. It is recommended that trimethoprim alone replace co-trimoxazole for the treatment of uncomplicated urinary tract infections.
本研究旨在比较单独使用甲氧苄啶（每日300毫克）与复方新诺明（每12小时0.96克）及磺胺甲噻二唑（每8小时1克）治疗普通门诊中单纯性尿路感染的疗效。所有患者均持续治疗五天。每组纳入20名患者。甲氧苄啶、复方新诺明和磺胺甲噻二唑的治愈率（治疗结束后一周尿液无菌）分别为90%、95%和90%。副作用极小。建议单独使用甲氧苄啶替代复方新诺明治疗单纯性尿路感染。
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