Simon O, Mertin J, Brass B
Med Klin. 1978 Mar 31;73(13):470-3.
EEG studies were done on patients with CNS disease who were treated with d-aldosterone and spirolactone. The baseline EEGs of these patients were found to be slightly abnormal. During infusion of the spirolactone derivative potassium canrenoate a transient deterioration of preexisting EEG disturbances was observed; in addition, bursts of increased muscle activity and transient relative bradycardia were seen. These findings indicate that potassium canrenoate or its lipophilic metabolite canrenone may affect the nervous system directly, possibly via a disturbance in the electrolyte balance. These results are compatible with recent findings in animal studies.
对患有中枢神经系统疾病并接受d-醛固酮和螺内酯治疗的患者进行了脑电图研究。发现这些患者的基线脑电图略有异常。在输注螺内酯衍生物坎利酸钾期间，观察到先前存在的脑电图紊乱出现短暂恶化；此外，还出现了肌肉活动增加的突发情况和短暂的相对心动过缓。这些发现表明，坎利酸钾或其亲脂性代谢产物坎利酮可能直接影响神经系统，可能是通过电解质平衡紊乱来实现的。这些结果与近期动物研究的结果相符。
