Madar I, Mihail N
Endocrinologie. 1983 Jan-Mar;21(1):37-42.
In three different age-groups (30-, 45- and 60-day-old) of normal and streptozotocin-diabetic rats the histological aspect of the endocrine pancreas and the blood glucose content were followed under basal conditions and against the background of hydrocortisone treatment (for 5 days with daily doses of 0.250 mg/100 g b.w.). It was established that in normal rats hydrocortisone affects characteristically the structure of pancreatic islets, but not glycemia homeostasis. In diabetic animals hydrocortisone aggravates the streptozotocin induced beta-cell damages of pancreatic islets and accentuates the diabetic hyperglycemia, depending on the age of individuals.
在正常大鼠和链脲佐菌素诱导的糖尿病大鼠的三个不同年龄组（30日龄、45日龄和60日龄）中，在基础条件下以及在氢化可的松治疗（每日剂量0.250mg/100g体重，持续5天）的背景下，观察内分泌胰腺的组织学特征和血糖含量。结果表明，在正常大鼠中，氢化可的松对胰岛结构有典型影响，但对血糖稳态无影响。在糖尿病动物中，氢化可的松会加重链脲佐菌素诱导的胰岛β细胞损伤，并加重糖尿病高血糖症，这取决于个体年龄。
