Heinzmann D, Nadrowitz R, Besch W, Schmidt W, Hahn H J
Exp Clin Endocrinol. 1983 Jan;81(1):94-7. doi: 10.1055/s-0029-1210213.
Irradiation of pancreatic rat islets up to a dose of 2.5 Gy did neither alter glucose-nor IBMX-induced insulin secretion studied in vitro. The insulin as well as glucagon content of irradiated islets were similar as in the control tissue. This was also true in islets irradiated with 25 Gy which were characterized by a decreased insulin secretion in the presence of glucose and IBMX, respectively. Since we did not find indications of an enhanced hormone output in the radiation medium, we want to suggest that higher irradiation doses affect insulin release of pancreatic islets in vitro. This observation has to be taken into account for application of radioimmunosuppression for transplantation.
对大鼠胰岛进行高达2.5 Gy剂量的照射，在体外研究中既未改变葡萄糖诱导的胰岛素分泌，也未改变IBMX诱导的胰岛素分泌。照射后胰岛的胰岛素和胰高血糖素含量与对照组织相似。在用25 Gy照射的胰岛中也是如此，这些胰岛的特征分别是在存在葡萄糖和IBMX时胰岛素分泌减少。由于我们在辐射培养基中未发现激素输出增加的迹象，我们认为较高的照射剂量会影响体外培养的胰腺胰岛的胰岛素释放。在将放射免疫抑制应用于移植时必须考虑到这一观察结果。
