Harrison R W
Int Rev Cytol Suppl. 1983;15:1-16. doi: 10.1016/b978-0-12-364376-6.50007-7.
Virtually all glucocorticoid effects are mediated through changes in gene transcription. Steroid binding to the receptor and nuclear binding of the steroid-receptor complex are pivotal events in this process, but may be modified by the ability of a given steroid to traverse the cell membrane or cause receptor activation. The physical nature of the receptor, its precise subcellular location, and the process by which gene activation is accomplished are unknown. Preparation of purified receptor and further characterization of the nuclear binding sites will be crucial to a better understanding of this process.
几乎所有糖皮质激素的作用都是通过基因转录的变化来介导的。类固醇与受体的结合以及类固醇 - 受体复合物的核内结合是这一过程中的关键事件，但可能会受到特定类固醇穿越细胞膜的能力或引起受体激活能力的影响。受体的物理性质、其精确的亚细胞定位以及基因激活的完成过程尚不清楚。制备纯化的受体并进一步表征核结合位点对于更好地理解这一过程至关重要。
