5-硫代-D-葡萄糖和胰岛素在体内对缺氧P388小鼠白血病的放射增强作用。

The radioenhancement effects of 5-thio-D-glucose and insulin in vivo on a hypoxic P388 murine leukemia.

作者信息

Belgrad R, Wampler G L, Hazra T

出版信息

Int J Radiat Oncol Biol Phys. 1983 May;9(5):713-6. doi: 10.1016/0360-3016(83)90239-0.

Abstract

A radioresistant in vivo tumor consisting of a partially hypoxic P388 murine leukemia growing intraperitoneally (IP) in B6D2F1 female mice was used to test the radioenhancement potential of 5-Thio-D-Glucose (5TDG) and insulin. Pretreated animals were exposed to increasing doses of whole body radiation (5, 10, 20 Gy) and harvested tumor cells were re-injected into new hosts. In this experiment little benefit was demonstrated with 5TDG or the combination of 5TDG and insulin + radiation. The median survival of animals receiving cells pre-treated with insulin and radiation was improved, but, in general, did not reach statistical significance by the log rank method.

摘要

一种由部分缺氧的P388小鼠白血病组成的耐辐射体内肿瘤，在B6D2F1雌性小鼠腹腔内生长，用于测试5-硫代-D-葡萄糖（5TDG）和胰岛素的辐射增强潜力。预处理的动物接受递增剂量的全身辐射（5、10、20 Gy），收获的肿瘤细胞重新注射到新的宿主中。在该实验中，5TDG或5TDG与胰岛素+辐射的组合几乎没有显示出益处。接受胰岛素和辐射预处理细胞的动物的中位生存期有所改善，但总体而言，通过对数秩检验方法未达到统计学意义。