Rockwell S, Schulz R J
Radiat Res. 1984 Dec;100(3):527-35.
The antineoplastic effects of the glucose analog 5-thio-D-glucose (5TG) were tested using EMT6 mouse mammary tumors in vivo and EMT6 cells in cell culture. In vitro, 5TG selectively killed hypoxic EMT6 cells. However, administration of 5TG to mice bearing EMT6 tumors produced no significant toxicity to the cells of unirradiated tumors and did not alter the survival of cells in irradiated tumors. Fasting the mice to lower blood glucose concentrations before administration of 5TG increased the toxicity of the drug to the mice, but did not allow more efficacious treatment of the tumors. The data provided no evidence that 5-thio-D-glucose can be used effectively for the treatment of solid tumors, either as a cytotoxic agent or as a radiosensitizer.
使用EMT6小鼠乳腺肿瘤在体内以及EMT6细胞在细胞培养中测试了葡萄糖类似物5-硫代-D-葡萄糖（5TG）的抗肿瘤作用。在体外，5TG选择性杀死缺氧的EMT6细胞。然而，给携带EMT6肿瘤的小鼠施用5TG对未照射肿瘤的细胞没有产生明显毒性，并且没有改变照射肿瘤中细胞的存活率。在施用5TG之前使小鼠禁食以降低血糖浓度增加了药物对小鼠的毒性，但没有实现对肿瘤更有效的治疗。数据没有提供证据表明5-硫代-D-葡萄糖可以作为细胞毒性剂或放射增敏剂有效地用于实体瘤的治疗。
