Weiss L
J Parasitol. 1983 Apr;69(2):307-18.
In P. berghei murine malaria, parasitized erythrocytes and nonparasitized reticulocytes were concentrated in the lumen of venous sinuses of bone marrow, adherent to endothelium and to one another. Merozoites maturing in erythrocytes contained in venous sinuses are so positioned against adherent reticulocytes that when they break out they can penetrate adherent reticulocytes without significant extracellular exposure. Merozoites from cells not adjacent to reticulocytes would spill into the plasma and be opsonized and phagocytized. The vascular sinuses of bone marrow therefore appear to be sites where erythrocytic parasitization is secured and where the severity and chronicity of the erythrocytic phase of the disease is regulated in P. berghei and, perhaps, other reticulocyte-prone malarias. In P. chabaudi, where fully mature erythrocytes rather than reticulocytes are preferentially parasitized, parasitized erythrocytes show far less predilection for bone marrow.
在伯氏疟原虫引起的鼠类疟疾中，被寄生的红细胞和未被寄生的网织红细胞集中在骨髓静脉窦腔内，它们附着于内皮细胞并相互粘连。在静脉窦内红细胞中成熟的裂殖子与粘连的网织红细胞位置相对，以至于当它们破裂时能够穿透粘连的网织红细胞，而无需在细胞外大量暴露。来自不与网织红细胞相邻细胞的裂殖子会溢入血浆，被调理素化并被吞噬。因此，骨髓血管窦似乎是确保红细胞被寄生的部位，也是伯氏疟原虫以及或许其他易感染网织红细胞的疟疾中，调节疾病红细胞期严重程度和慢性病程的部位。在查巴迪疟原虫感染中，优先被寄生的是完全成熟的红细胞而非网织红细胞，被寄生的红细胞对骨髓的偏好要小得多。
