Knysh V I, Aliev B M, Barsukov Iu A
Med Radiol (Mosk). 1983 May;28(5):12-7.
The paper is concerned with the results of a randomized study of 154 patients with rectal cancer. Of these, 76 were on combination therapy and 78 underwent surgical treatment alone. Preoperative gamma-therapy was given from open fields at a single dose of 4-5 Gy with a summary dose of 20-25 Gy, or by using a grid diaphragm at a single dose of 10 Gy up to a summary dose of 50 Gy. Irradiation was followed by surgical intervention in 3-5 days. The analysis of immediate therapeutic results has shown that the above variants of preoperative irradiation are well tolerated and do not cause an increase either in the number of postoperative complications or lethal cases. Combination therapy improves long-term results and causes a significant decrease (more than thrice) in the frequency of postoperative cancer recurrences. The treatment has proved to be the most effective in patients with a locally disseminated process and an unfavorable prognosis.
该论文关注的是154例直肠癌患者的随机研究结果。其中，76例接受联合治疗，78例仅接受手术治疗。术前γ射线治疗采用开放野，单次剂量为4 - 5 Gy，总剂量为20 - 25 Gy；或使用格栅式铅挡器，单次剂量为10 Gy，总剂量达50 Gy。照射后3 - 5天进行手术干预。近期治疗结果分析表明，上述术前照射方案耐受性良好，术后并发症数量或致死病例数均未增加。联合治疗可改善长期疗效，并使术后癌症复发频率显著降低（超过三倍）。该治疗方法在局部扩散性病变且预后不良的患者中被证明是最有效的。
