Experimental investigations on sensitivity to nickel present in alloys used in dentistry carried out on guinea pigs previously sensitized to this metal.

Experimental investigation on sensitivity to nickel present in dental alloys has been carried out on guinea pigs previously sensitized to this metal. The metal plates containing nickel have been sutured to the oral mucosa in such a way that condition of alloys contact with mucosa were possible similar to those present in the mouth of the patient wearing fixed prosthesis. The results of macro and micro examination has not shown any morphological differences between experimental and control material.