Baldwin W M, Claas F H, Paul L C, Springer T A, Hendriks G F, van Es L A, van Rood J J
Tissue Antigens. 1983 Mar;21(3):254-9. doi: 10.1111/j.1399-0039.1983.tb00166.x.
Recently a tissue restricted antigen system, which is expressed on endothelial cells and monocytes (E-M antigens) but not lymphocytes, has been associated with kidney graft rejection. In screening sera from recipients of kidney, bone marrow or skin grafts for possible reactivity with endothelial cell antigens, we have found that all (13 of 13) endothelial reactive sera also reacted with monocytes, but that many (21 of 34) monocyte reactive sera did not react with endothelial cells. Additionally, one well-defined monoclonal antibody (M1/70), which was cytotoxic for human monocytes, neither stained renal endothelium nor was absorbed by renal endothelium when perfused through a human kidney. Thus, not all monocyte antigens appear to be expressed in high concentrations on renal vascular endothelium. This may explain why monocyte reactive antibodies do not always correlate with kidney graft rejection.
最近，一种组织限制性抗原系统已被证实与肾移植排斥反应有关，该系统在内皮细胞和单核细胞（E-M抗原）上表达，但在淋巴细胞上不表达。在筛查肾、骨髓或皮肤移植受者血清与内皮细胞抗原的可能反应性时，我们发现所有（13例中的13例）与内皮细胞反应的血清也与单核细胞发生反应，但许多（34例中的21例）与单核细胞反应的血清不与内皮细胞发生反应。此外，一种明确的单克隆抗体（M1/70）对人单核细胞具有细胞毒性，当灌注人肾时，它既不染色肾内皮，也不被肾内皮吸收。因此，并非所有单核细胞抗原似乎都在肾血管内皮上高浓度表达。这可能解释了为什么与单核细胞反应的抗体并不总是与肾移植排斥反应相关。
