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全身照射后大鼠垂体-肾上腺轴的活性。与4例人类长期全身照射中血浆皮质醇变化的比较。

Pituitary-adrenal axis activity in rats after whole-body irradiation. Comparison with plasma cortisol evolution in four cases of human protracted whole-body irradiation.

作者信息

Coffigny H, Pasquier C

出版信息

Strahlentherapie. 1983 Apr;159(4):242-5.

PMID:6344347
Abstract

Plasma ACTH and adrenal and plasma corticosterone levels were studied in rats during 30 days after LD50 irradiation. Plasma cortisol levels were studied in man after protracted whole-body irradiation. In both cases, a period of great instability of adrenal function was associated with bad clinical conditions. Then, a period of adrenal dysfunctioning, reversible with time, occurred in rats and in one patient.

摘要

研究了半数致死剂量辐射后30天内大鼠的血浆促肾上腺皮质激素(ACTH)、肾上腺及血浆皮质酮水平。还研究了长期全身照射后人的血浆皮质醇水平。在这两种情况下,肾上腺功能的高度不稳定期均与不良临床状况相关。随后,大鼠和一名患者出现了肾上腺功能障碍期,且该障碍随时间可逆转。

相似文献

1
Pituitary-adrenal axis activity in rats after whole-body irradiation. Comparison with plasma cortisol evolution in four cases of human protracted whole-body irradiation.全身照射后大鼠垂体-肾上腺轴的活性。与4例人类长期全身照射中血浆皮质醇变化的比较。
Strahlentherapie. 1983 Apr;159(4):242-5.
2
Late adrenal dysfunctioning after whole-body irradiation of rats.大鼠全身照射后晚期肾上腺功能障碍
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Plasma and adrenal corticosterone levels in male rats following x-irradiation at different times of day.雄性大鼠在一天中不同时间接受X射线照射后的血浆和肾上腺皮质酮水平
Folia Biol (Praha). 1978;24(1):59-67.
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Effect of dexamethasone on pituitary-adrenocortical response to acute irradiation stress in rats.
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[Cortisol and corticosterone levels in adrenal glands and plasma in the newborn guinea pig].新生豚鼠肾上腺和血浆中的皮质醇和皮质酮水平
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The role of corticosterone in human hypothalamic-pituitary-adrenal axis feedback.皮质酮在人类下丘脑-垂体-肾上腺轴反馈中的作用。
Clin Endocrinol (Oxf). 2006 Jul;65(1):22-6. doi: 10.1111/j.1365-2265.2006.02540.x.
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["Late" activation of the functions of the hypophyseal-adrenal system after irradiation].[照射后垂体 - 肾上腺系统功能的“晚期”激活]
Radiobiologiia. 1975 Jul-Aug;15(4):621-4.
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Whole-body irradiation transiently diminishes the adrenocorticotropin response to recombinant human interleukin-1 alpha.全身照射会暂时减弱促肾上腺皮质激素对重组人白细胞介素-1α的反应。
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Paradoxical sleep deprivation and sleep recovery: effects on the hypothalamic-pituitary-adrenal axis activity, energy balance and body composition of rats.异相睡眠剥夺与睡眠恢复:对大鼠下丘脑 - 垂体 - 肾上腺轴活性、能量平衡及身体组成的影响
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