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[免疫荧光在肾脏疾病诊断中的价值]

[Value of immunofluorescence in the diagnosis of kidney diseases].

作者信息

Schneider W

出版信息

Z Gesamte Inn Med. 1983 Feb 15;38(4):115-20.

PMID:6344465
Abstract

In the diagnostics of renal diseases the direct immunofluorescence has become a necessary morphological method for proving immunopathological glomerular, tubulo-interstitial or vascular processes. On the basis of characteristic patterns of findings glomerulonephritides and tubulo-interstitial nephritides may be differed by antibodies of basal membranes as well as glomerulonephritides, tubulo-interstitial nephritides and vasculitides by deposition of circulating or locally developed immune complexes. Apart from immunopathogenetic characteristics localization, intensity and expansion as well as immunochemical peculiarities of depositions of immune complexes are of importance for further characterization. As an indirect method the immunofluorescence is suitable for proving circulating antibodies against renal constituents.

摘要

在肾脏疾病的诊断中,直接免疫荧光已成为一种必要的形态学方法,用于证实免疫病理学的肾小球、肾小管间质或血管病变。根据特征性的检查结果模式,肾小球肾炎和肾小管间质性肾炎可通过基底膜抗体进行区分,肾小球肾炎、肾小管间质性肾炎和血管炎也可通过循环或局部形成的免疫复合物沉积来区分。除了免疫发病机制特征外,免疫复合物沉积的定位、强度和范围以及免疫化学特性对于进一步的特征描述也很重要。作为一种间接方法,免疫荧光适用于证实针对肾脏成分的循环抗体。

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