Wilson C B
Fed Proc. 1977 Jul;36(8):2171-5.
Anti-basement membrane antibodies and tissue deposition of immune complexes appear to be responsible for most glomerulonephritides and for some tubulo-interstitium injury accompanying glomerulonephritis or occuring primarily. Anti-tubular basement membrane antibodies complicate immunologic and toxic renal injury, including transplantation, and widespread tubulo-intersitial immune complex deposits are present in most patients with systemic immune complex disease, such as lupus erythematosus. Radioimmunoassay is now available for detecting and monitoring circulating anti-glomerular basement membrane antibodies. The effect of aggressive therapy with immunosuppression and plasma exchange is being studied to determine is value in minimizing tissue damage produced by the usual transient production of anti-glomerular basement membrane antibodies. Techniques are being explored to detect circulating immune complexes. Vigorous efforts are under way to identify antigen-antibody systems involved in the production of nephritogenic immune complexes, which may lead to antigen irradiation or specific manipulation of the immune response or its products.
抗基底膜抗体和免疫复合物的组织沉积似乎是大多数肾小球肾炎以及一些伴随肾小球肾炎或主要发生的肾小管间质损伤的原因。抗肾小管基底膜抗体使免疫性和中毒性肾损伤（包括移植）复杂化，并且在大多数系统性免疫复合物疾病（如红斑狼疮）患者中存在广泛的肾小管间质免疫复合物沉积。现在可以通过放射免疫测定法检测和监测循环中的抗肾小球基底膜抗体。正在研究免疫抑制和血浆置换的积极治疗效果，以确定其在最小化通常短暂产生的抗肾小球基底膜抗体所造成的组织损伤方面的价值。正在探索检测循环免疫复合物的技术。正在大力努力确定参与产生致肾炎免疫复合物的抗原 - 抗体系统，这可能导致抗原照射或对免疫反应及其产物进行特异性调控。
