Baum J
Am J Med. 1983 Jun 14;74(6A):10-5. doi: 10.1016/0002-9343(83)90523-5.
Aspirin can be more closely controlled than other nonsteroidal anti-inflammatory drugs because serum salicylate levels can be measured. Dosages of 80 to 100 mg/kg per day usually lead to the desired serum salicylate levels of 20 to 25 mg/dl. Gastric irritation, the most frequent cause for cessation of aspirin therapy, is significantly reduced by the use of enteric-coated aspirin. At the onset of aspirin therapy in children, there is frequently moderate elevation of SGOT and SGPT liver enzyme levels. With continued treatment these levels usually fall into the range of mild elevations. Although these children with arthritis often take high doses of aspirin for years, Reye's syndrome is virtually never seen.
与其他非甾体抗炎药相比，阿司匹林的用量可以得到更严格的控制，因为可以检测血清水杨酸水平。每天80至100毫克/千克的剂量通常会使血清水杨酸水平达到理想的20至25毫克/分升。使用肠溶阿司匹林可显著减少阿司匹林治疗中最常见的停药原因——胃部刺激。在儿童开始使用阿司匹林治疗时，血清谷草转氨酶（SGOT）和谷丙转氨酶（SGPT）水平常常会出现中度升高。持续治疗后，这些水平通常会降至轻度升高的范围。尽管这些患有关节炎的儿童常常多年服用高剂量的阿司匹林，但几乎从未出现过瑞氏综合征。
