末端脱氧核苷酸转移酶在白血病诊断中的应用。
Use of terminal deoxynucleotidyl transferase in the diagnosis of leukemia.
作者信息
Morse E E, Gaffney J, Donskoy E, Pisciotto P, Altman A, Quinn J, Goldschneider I
出版信息
Ann Clin Lab Sci. 1983 Mar-Apr;13(2):128-32.
Terminal deoxynucleotidyl transferase (TdT) was determined by immunofluorescence in 30 patients with leukemia. In acute lymphocytic leukemia the proportion of cells positive for TdT was 19 to 77 percent during relapse (12 cases) and less than one percent during remission (three cases). In seven cases of myeloproliferative disease and two cases of lymphoma, the TdT was less than one percent. In one case of generalized lymphoblastic lymphoma and five cases of chronic myelocytic leukemia with "lymphoblastic" crisis, the cells positive for TdT were moderately increased. The presence of TdT in blast cells appears to have diagnostic, therapeutic, and prognostic significance.
采用免疫荧光法对30例白血病患者的末端脱氧核苷酸转移酶（TdT）进行了检测。在急性淋巴细胞白血病患者中，复发期（12例）TdT阳性细胞比例为19%至77%，缓解期（3例）则低于1%。在7例骨髓增殖性疾病和2例淋巴瘤患者中，TdT低于1%。在1例全身性淋巴母细胞淋巴瘤和5例处于“淋巴母细胞”危象的慢性粒细胞白血病患者中，TdT阳性细胞适度增加。原始细胞中TdT的存在似乎具有诊断、治疗及预后意义。
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