Ohnishi H, Kosuzume H, Ashida Y, Kato K, Suzuki Y, Honjo I
Nihon Yakurigaku Zasshi. 1983 Mar;81(3):235-44.
Therapeutic effects of human urinary trypsin inhibitor (MTI) on acute pancreatitis were examined. MTI potently inhibited not only proteases such as trypsin or alpha-chymotrypsin, but also inhibited lipase or creatine phosphokinase which are considered to be related to pancreatitis. Although gabexate mesilate (gabexate) and aprotinin also strongly inhibited trypsin, their inhibition spectra against pancreatic enzymes were narrower and aprotinin also strongly inhibited trypsin, their inhibition against pancreatic enzymes were narrower than MTI. MTI inhibited proteases released from pancreatic slice by trypsin more potently than gabexate or aprotinin. The therapeutic effects of MTI on experimental acute trypsin-induced pancreatitis in dogs or rats were stronger than those of gabexate or aprotinin. These results suggest that MTI may suppress pathogenesis and development of pancreatitis in several ways, for example, by directly inhibiting trypsin and by inhibiting tissue-damaging enzymes released from the pancreas by stimulation with trypsin.
研究了人尿胰蛋白酶抑制剂（MTI）对急性胰腺炎的治疗作用。MTI不仅能有效抑制诸如胰蛋白酶或α-糜蛋白酶等蛋白酶，还能抑制被认为与胰腺炎相关的脂肪酶或肌酸磷酸激酶。虽然甲磺酸加贝酯（加贝酯）和抑肽酶也能强烈抑制胰蛋白酶，但它们对胰腺酶的抑制谱比MTI更窄。MTI比加贝酯或抑肽酶更有效地抑制胰蛋白酶从胰腺切片释放的蛋白酶。MTI对犬或大鼠实验性急性胰蛋白酶诱导的胰腺炎的治疗作用比加贝酯或抑肽酶更强。这些结果表明，MTI可能通过多种方式抑制胰腺炎的发病机制和发展，例如，通过直接抑制胰蛋白酶以及抑制胰蛋白酶刺激胰腺释放的组织损伤酶。
