单次口服甲硝唑治疗青春期女性加德纳菌性阴道炎

Single oral dose metronidazole therapy for Gardnerella vaginalis vaginitis in adolescent females.

作者信息

Minkowski W L, Baker C J, Alleyne D, Baghai M, Friedlander L, Schultz B

出版信息

J Adolesc Health Care. 1983 Jun;4(2):113-6. doi: 10.1016/s0197-0070(83)80030-8.

Abstract

This study briefly reviews Gardnerella vaginalis as a primary vaginal pathogen and assesses the efficacy and safety of therapy with a single, 2-g oral dose of metronidazole. Over a period of 20 months, 882 symptomatic adolescent girls had positive cultures for G. vaginalis. All were post-menarcheal. No other vaginal pathogen was isolated in 609. The total group had a second culture 5-7 days after treatment. Cultures taken after treatment were negative in 95% of those treated with a single 2-g dose of metronidazole. Symptoms abated with therapy and culture negativity. Side effects were limited to infrequent, minor gastric distress. Our results suggest the utility of a simplified, one-dose regimen with high efficacy, insignificant side effects, and a lower cost per patient than the current dosage schedule of 500 mg b.i.d. for 7 days.

摘要

本研究简要回顾了阴道加德纳菌作为主要阴道病原体的情况，并评估了单剂量口服2克甲硝唑治疗的疗效和安全性。在20个月的时间里，882名有症状的青春期女孩阴道加德纳菌培养呈阳性。所有患者均已月经初潮。609名患者未分离出其他阴道病原体。所有患者在治疗后5至7天进行第二次培养。单剂量口服2克甲硝唑治疗的患者中，95%治疗后的培养结果为阴性。症状随着治疗和培养转阴而减轻。副作用仅限于偶尔出现的轻微胃部不适。我们的结果表明，简化的单剂量方案具有高效、副作用不明显且每位患者成本低于当前500毫克每日两次、连服7天的给药方案的效用。