Rosas S B, Calzolari A, La Torre J L, Ghittoni N E, Vásquez C
J Bacteriol. 1983 Jul;155(1):402-6. doi: 10.1128/jb.155.1.402-406.1983.
A plasmid-containing wild-type Escherichia coli strain was treated with two plasmid-curing agents, sodium dodecyl sulfate and ethidium bromide. Plasmid elimination was accompanied by drastic changes in the morphology of the colonies. Analysis of the cured strain by scanning and transmission electron microscopy showed important alterations in size and morphology of the cells. Metabolic differences were also found between the wild-type and cured cells.
一个含有质粒的野生型大肠杆菌菌株用两种质粒消除剂（十二烷基硫酸钠和溴化乙锭）进行处理。质粒消除伴随着菌落形态的剧烈变化。通过扫描电子显微镜和透射电子显微镜对消除质粒后的菌株进行分析，结果显示细胞的大小和形态发生了显著改变。野生型细胞和消除质粒后的细胞之间也发现了代谢差异。
