Bell F E, Palmer J S, Dawson W D
J Exp Zool. 1983 May;226(2):273-9. doi: 10.1002/jez.1402260213.
Effects of exogenous medroxyprogesterone acetate (MPA) on skin transplant retention and conceptus size were studied in the deer mouse, Peromyscus maniculatus, and the oldfield mouse Peromyscus polionotus. Daily injections of 2 mg MPA significantly prolonged survival of allografts in P. maniculatus and transspecific grafts between P. maniculatus and P. polionotus. Allografts were retained significantly longer than transspecific grafts (17.2 vs 12.4 days) on MPA-treated P. maniculatus. Near-term fetal and placental sizes and weights were not detectably influenced by daily 1-mg MPA injections given to the mother from the 5th through the 19th day of pregnancy. The data are discussed relative to the possible immunosuppressive role of progestins in protecting the allogeneic conceptus from maternal immune rejection.
在鹿鼠（白足鼠）和旧域鼠中研究了外源性醋酸甲羟孕酮（MPA）对皮肤移植存活时间和胚胎大小的影响。每天注射2毫克MPA可显著延长白足鼠同种异体移植以及白足鼠和旧域鼠之间种间移植的存活时间。在接受MPA治疗的白足鼠中，同种异体移植的保留时间明显长于种间移植（17.2天对12.4天）。从怀孕第5天到第19天，每天给母亲注射1毫克MPA对近期胎儿和胎盘的大小及重量未产生明显影响。讨论了这些数据与孕激素在保护同种异体胚胎免受母体免疫排斥中可能的免疫抑制作用的相关性。
