使用BB/W大鼠淋巴组织移植未能将胰岛炎转移至无胸腺受体。
Failure to transfer insulitis to athymic recipients using BB/W rat lymphoid tissue transplants.
作者信息
Rossini A A, Mordes J P, Williams R M, Pelletier A M, Like A A
出版信息
Metabolism. 1983 Jul;32(7 Suppl 1):80-2. doi: 10.1016/s0026-0495(83)80016-x.
PMID:6345997
Abstract
Lymphocytes from acutely diabetic BB/W rats were transplanted into SWR/JM nu/nu athymic mice and nu/nu athymic rats. Despite the use of a wide variety of dose regimens and pretreatments, no recipient developed either insulitis, hyperglycemia, or glucose intolerance. These data contradict earlier reports of successful transfer of insulitis using similar methodology.
摘要
将急性糖尿病BB/W大鼠的淋巴细胞移植到SWR/JM裸/裸无胸腺小鼠和裸/裸无胸腺大鼠体内。尽管使用了多种剂量方案和预处理方法，但没有一只受体出现胰岛炎、高血糖或葡萄糖不耐受。这些数据与早期使用类似方法成功转移胰岛炎的报道相矛盾。
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