Weringer E J, Like A A
Am J Pathol. 1986 Oct;125(1):107-12.
Spontaneous diabetes mellitus in the BioBreeding/Worcester (BB/W) rat is preceded by lymphocytic insulitis which destroys pancreatic beta cells. Cultured major histocompatibility complex identical pancreatic islets and adrenal cortex derived from diabetes-resistant BB/W donors were transplanted into diabetic recipients with hyperglycemia of variable duration. Islet grafts were the targets of BB/W immune attack and revealed lymphocytic insulitis after transplantation into diabetic recipients even in the absence of insulitis within endogenous pancreatic islets. These findings suggest that the BB/W immune attack on pancreatic beta cells can recur in islet grafts long after the onset of the diabetic syndrome.
生物繁殖/伍斯特（BB/W）大鼠的自发性糖尿病之前会出现淋巴细胞性胰岛炎，这种炎症会破坏胰腺β细胞。将来自抗糖尿病的BB/W供体的培养的主要组织相容性复合体相同的胰岛和肾上腺皮质移植到患有不同病程高血糖症的糖尿病受体中。胰岛移植是BB/W免疫攻击的目标，即使内源性胰腺胰岛中不存在胰岛炎，移植到糖尿病受体后也会出现淋巴细胞性胰岛炎。这些发现表明，在糖尿病综合征发病很久之后，BB/W对胰腺β细胞的免疫攻击仍可能在胰岛移植中复发。
