Weinberger D R, Wagner R L, Wyatt R J
Schizophr Bull. 1983;9(2):193-212. doi: 10.1093/schbul/9.2.193.
Over the past 20 years, there has been a relatively quiet but persistent effort to investigate anatomical neuropathology in schizophrenia. This effort has involved post-mortem histopathology using novel preparation procedures, pneumoencephalography, and computed tomography. The bulk of this research is critically reviewed here. The evidence presented suggests that the brains of schizophrenic patients frequently contain abnormalities. The limbic region is especially likely to show pathological changes. However, the changes are variable and nonspecific. The implications of these findings are discussed in terms of our limited knowledge of the clinical manifestations of subtle limbic pathology. It is concluded that pathology of limbic regions is associated with schizophrenia and that the more gross the pathology, the more neurologically impaired are the patients.
在过去20年里，人们一直在相对平静但持续不断地努力研究精神分裂症的解剖神经病理学。这项工作涉及使用新颖制备程序的尸检组织病理学、气脑造影术和计算机断层扫描。本文对这项研究的大部分内容进行了批判性综述。所呈现的证据表明，精神分裂症患者的大脑经常存在异常。边缘区域尤其容易出现病理变化。然而，这些变化是可变的且不具有特异性。鉴于我们对细微边缘病理临床表现的了解有限，对这些发现的意义进行了讨论。得出的结论是，边缘区域的病理与精神分裂症有关，而且病理越严重，患者的神经功能受损越严重。
