Ladisch S, Pizzo P A
Pediatrics. 1978 Feb;61(2):231-4.
Seventy episodes of Staphylococcus aureus sepsis occurring over a nine-year period in pediatric cancer patients are reviewed. Prominent findings at the time of diagnosis included fever, granulocytopenia, and active malignancy. Probable or suspected sites of primary infection were present in 40 episodes (57%). Serious direct complications of staphylococcal sepsis included only three cases of pneumonia and one of myositis. However, second infections by other organisms developed in 16 episodes (24%), resulting in nine nonstaphylococcal infectious deaths during therapy. Endocarditis and osteomyelitis never occurred in this group of patients. The median duration of antistaphylococcal therapy was 15 days.
回顾了小儿癌症患者在九年期间发生的70例金黄色葡萄球菌败血症病例。诊断时的突出表现包括发热、粒细胞减少和活动性恶性肿瘤。40例（57%）存在可能或疑似的原发性感染部位。葡萄球菌败血症的严重直接并发症仅包括3例肺炎和1例肌炎。然而，16例（24%）发生了其他病原体的二次感染，导致治疗期间9例非葡萄球菌感染死亡。该组患者从未发生心内膜炎和骨髓炎。抗葡萄球菌治疗的中位持续时间为15天。
